Completely draining and refilling the cooling system at least every two years will remove accumulated rust, scale and other deposits. Coolant in late model trucks is a 50/50 mixture of ethylene glycol and water for year round use. Use a good quality antifreeze with water pump lubricants, rust inhibitors and other corrosion inhibitors along with acid neutralizers.
CAUTION
When draining the coolant, keep in mind that cats and dogs are attracted
by the ethylene glycol antifreeze, and are quite likely to drink any that
is left in an uncovered container or in puddles on the ground. This will
prove fatal in sufficient quantity. Always drain the coolant into a sealable
container. Coolant should be reused unless it is contaminated or several
years old.
NOTE: Before opening the radiator petcock, spray it with some penetrating lubricant.